NOT KNOWN FACTS ABOUT METHADONE INTOXICATION

noted that rifampicin increased the metabolism of R- and S-methadone while the CYP3A selective inhibitor troleandamycin didn't have any effect over the enantiomers.Get baseline ECG (Assess QTc interval) before therapy in patients with danger factors for QTc interval prolongation, a prior ECG with a QTc >450 msec, or possibly a history suggesting pr